This journal article presents the results of a systematic review of peer reviewed literature on mHealth projects in Africa between 2003 and 2013. It documents strengths, weaknesses, opportunities and threats of mHealth projects from 44 studies. In general, the mHealth projects demonstrate positive health-related outcomes and their success is based on the accessibility, acceptance and low-cost of the technology, effective adaptation to local contexts, strong stakeholder collaboration, and government involvement. Threats such as dependency on funding, unclear healthcare system responsibilities, unreliable infrastructure and lack of evidence on cost-effectiveness challenge their implementation. It concludes that mHealth in Africa is an innovative approach to delivering health services.